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Active and Upcoming Projects 


Smart-T 3 (R01CA221819)

PI: Michael Businelle

This NCI R01 randomized clinical trial (N=450) will compare the longer-term effects of the Smart-T smoking cessation app (see above app screenshot)with the free and publicly available NCI QuitGuide smoking cessation app (Aim 1). The second aim of the proposed study will determine if Smart-T messages that are tailored to address key smoking lapse risk variables in real-time (i.e., urge, stress, cigarette availability, cessation motivation) reduce participant ratings of these lapse risk variables compared with similar situations that do not receive this tailored content (QuitGuide group). For more information, visit the study's ResearchGate page here.

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Link2Care (R01MD010733)


PIs: Michael Businelle & Jennifer Reingle Gonzalez

This 3-armed NIH R01 is a randomized clinical trial that will use an innovative smartphone application to identify and address barriers that prevent recently incarcerated homeless adults from obtaining available case management, crisis management, substance abuse, and mental health services. For study updates, visit the study's ResearchGate page here.

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PIs: Michael Businelle and Michael Zvolensky

Utilizing a precision medicine approach, the Easing Anxiety Sensitivity for Everyone (EASE) app targets anxiety sensitivity, a transdiagnostic individual difference factor implicated in the etiology, maintenance, and progression of anxiety and depressive symptoms. EASE includes COVID-19 symptom monitoring, exposure management skills, and psychoeducation on COVID-19-related stress and the impact of stress on susceptibility to infection and disease progression. Participants (N = 800; 200 Black, 200 Latinx, 200 American Indian, and 200 NLW) will be randomized to either EASE or to an active standard-of-care control digital intervention (Headspace app) for anxiety and depression.

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PI: Michael Businelle & Rachel Funk-Lawler

This pilot randomized controlled trial ( N=60) will assess the initial feasibility of a phone-delivered intervention for anxiety and depressive symptoms among cancer patients that are receiving active radiation treatments.

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HEALTH Center for Addictions Research and Cancer Prevention


PI: Obasi; Project MPIs: Businelle & Zvolensky

The aim of this study is to refine and evaluate an initially developed and tested, novel, mobile intervention that targets sensitivity to bodily sensations among African American smokers and bridges the gap in access to care which has plagued this health disparities population

Smart-T Mental Health
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Smart-T Mental Health

PIs: Michael Businelle and Adam Alexander

This pilot randomized controlled trial (N=75) will evaluate the feasibility of an innovative, evidence-based smoking cessation app tailored for smokers with serious mental illness (SMI).

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PIs: Michael Businelle and Emily Hébert

The purpose of the 32 group MOST design is to identify the optimal components, or combinations of components, for achieving the highest compliance rates for smartphone-based ecological momentary assessments (EMAs).



PI: Michael Businelle

This study (N=500) is a randomized controlled trial that will evaluate the feasibility and initial efficacy of an innovative, evidence-based smoking cessation app tailored for smokers that contact the Oklahoma Tobacco Helpline for services.

Completed Projects


PI: Michael Businelle  

This pilot study (N=150) is a 3-armed randomized controlled smoking cessation induction trial that will determine the initial utility of a novel smartphone based intervention compared with an attention control group among smokers who are not ready to quit. 

Symptom Tracker

PI: Michael Businelle & Katherine Moxley

The Symptom Tracker study (N=500) is recruiting OU Health Stephenson Cancer Center patients during chemotherapy infusion visits. The Symptom Tracker app (see above app screenshot) monitors symptoms (daily for 24 weeks) that are consistent with early signs of SARS-CoV-2 infection and automatically (and securely) transfers this information to health care providers. The primary aim of this study is to determine the feasibility, ease of use, and perceived utility of this app to monitor symptoms and health risk behaviors among cancer patients currently receiving chemotherapy.

Smart-T Alcohol 

PIs: Michael Businelle & Scott Walters 

This 2 phase NIH Funded R34 aims to develop and test a “just in time” adaptive intervention to reduce alcohol use in homeless men and women. Phase I utilizes smartphones and passive sensing technologies to monitor geolocation, psychosocial variables (e.g., stress, affect, urge to drink), and alcohol use (SCRAM). Phase II will use this information to provide tailored treatment messages that anticipate and intervene to prevent drinking and heavy drinking. For more information, visit the study's ResearchGate page here.

Smoking Cessation for American Indians with Diabetes 

​Investigators: Jennifer Vidrine, Darla Kendzor, Damon Vidrine, Michael Businelle 

The purpose of this pilot study is to identify factors that predict smoking lapse among smokers who attend a Choctaw Nation Hospital Diabetes Clinic.


PI: Michael Businelle

The primary long-term objective of this research is to reduce smoking relapse through the use of automated mobile smoking cessation interventions that tailor content in real-time based upon currently present symptoms. The primary short-term objective of this pilot study is to determine the initial utility of a novel smartphone based smoking cessation intervention compared with standard in-person smoking cessation clinic care and a free smoking cessation application. For more information, visit the study's ResearchGate page here.

Anxiety Sensitivity: M-ICART 

PIs: Michael Businelle, Michael Zvolensky, & Julia Buckner

The purpose of this pilot project is to translate our previously tested Integrated Cannabis and Anxiety Reduction Treatment [ICART] into a novel, mobile intervention for Cannabis Use Disorders. 

Anxiety Sensitivity: MASP

PIs: Michael Businelle & Michael Zvolensky 

The purpose of this pilot study is to feasibility test a novel, mobile intervention for smokers with high anxiety sensitivity (AS). This Mobile Anxiety Sensitivity Program for Smoking (MASP) integrates interoceptive exposure, emotion regulation, cognitive restructuring, and psychoeducation exercises developed from our past work in conjunction with standard smoking cessation strategies and nicotine replacement therapy. 

​Advance II

PI: Michael Businelle

The primary objective of this study is to gain a better understanding of the prevalence of physical and mental health issues among homeless adults in Oklahoma City. The secondary objective is to identify risk and protective factors that have an impact on health behavior and health behavior change in this understudied and underserved population. This information will improve understanding of the health needs of this marginalized group and will provide guidance to our future intervention work with homeless Oklahomans. For more information, visit the study's ResearchGate study page here.


PI: Michael Businelle

The primary objective of this project was to examine homeless individuals’ attitudes and beliefs about partial and full smoking bans at a local shelter before and after a partial smoking ban is implemented and to examine the short-term consequences of this ban. The secondary objective of this study was to determine the prevalence of modifiable cancer risk factors among a sample of homeless individuals. For more information, visit the study's ResearchGate study page here.


PIs: Michael Businelle & Darla Kendzor

This study will determine if low SES increases the odds of relapse through a number of hypothesized mechanisms. This work is innovative because it will explore mediational pathways between SES and smoking cessation among individuals of varying racial/ethnic backgrounds from two distinct samples, using both traditional (questionnaire) and state-of-the-science real-time assessment methodology. This information was used to develop a new smart phone–based smoking cessation treatment that assesses relapse risk in real time and automatically intervenes to reduce risk.


PIs: Michael Businelle & Darla Kendzor

The primary objectives of this study were: 1) to evaluate the efficacy of an adjunctive contingency management intervention for smokers of low socioeconomic status participating in a smoking cessation program at an urban safety net clinic (Parkland Tobacco Cessation Clinic), and 2) to identify barriers to smoking cessation and predictors of relapse in this population. For more information, visit the study's ResearchGate study page here.


PI: Michael Businelle


The primary objectives of this pilot project were to: 1) determine if ecological momentary assessment (EMA) methodology could be used to identify predictors of and barriers to successful smoking cessation in treatment seeking homeless smokers, and 2) determine if an adjunctive contingency management treatment component (i.e., small financial incentives for biologically confirmed abstinence) would increase abstinence relative to usual care in this population. For more information, visit the study's ResearchGate study page here.

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